Neurology . node-negative patients, and (2) those for which the risks and costs of adjuvant therapy outweigh the expected benefit.3 In this context, prognostic factors should be distinguished from predictive factors. Positive inguinal nodes and positive margins were identified as prognostic factors either for overall survival and disease specific survival; tumor size greater than 4 cm was identified as prognostic factors for overall survival. Experimental Design: Histopathologic specimens in 188 of 302 patients were analyzed for Ki-67, p16, maspin, Bcl-2, Her2/neu, and p53. For lower-risk patients, especially those who are node negative, an individualized assessment utilizing other prognostic factors must be performed. Methods: Clinical characteristics of patients were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Calcifications in or out of a mass were associated with most of the poor prognostic factors: high histological grade, positive EIC, negative ER status and positive HER-2/neu status . A high result can be interpreted as indicating the accuracy of such a statistic. The PPV and NPV describe the performance of a diagnostic test or other statistical measure. Prognostic factor defined as measurement taken at time of diagnosis or treatment that is associated with outcome. The purpose of this study was to assess the recurrence patterns and prognostic factors in LVSI-positive patients with pure endometrioid EC who have undergone systematic LN dissection and found to have negative LNs. The addition of erbB-2, EGFR, or Gt (as either continuous or dichotomous variables) failed to provide improvement in survival prediction (although the statistical power was decreased in this subset because of fewer events). Negative prognostic factors for head and neck cancer in the young K. Kourelis 1 , T. Tsue 1 , D. Girod 1 , O. Tawfik 2 , K. Sykes 1 , Y. Shnayder 1 Kansas University Medical Center, 1 Department of Otolaryngology and 2 Department of Pathology, Kansas City, KS, Find out more about HER2 status testing. Predictive factor is a measurement that predict response or lack of response to a specific treatment. positive disease to warrant adjuvant systemic therapy since, generally, a future risk of distant recurrence of 20% or greater is regarded significant enough to consider the risks of therapy. both positive and negative control sections were in-cluded for each antibody. Conclusions 2017; 8: 44870-80, CrossRef. In 109 patients with node-negative large tumour (Group 1), recurrence developed in 44 (40%) and cancer-related death was the outcome in 38 (35%) patients during 45 months of median follow-up time. Multivariate analyses of survival were performed by Cox proportional hazards models incorporating the prognostic factors identified in the univariate log rank test. in lymph node-negative patients was 33.0 months, and in lymph node- positive patients, it was 19.0 months. The HER2 status was as follows: negative in 751 cases, 1+ in 440 cases, 2+ in 123 cases, and 3+ in 238 cases. We conducted a retrospective analysis to examine the clinical characteristics and prognostic factors in HIV-negative and HIV-positive patients with PCNSL and to assess the effect of highly active antiretroviral therapy (HAART) therapy on the outcome of HIV-positive patients. Dutch Guillain-Barré Study Group. Triple-negative invasive ductal carcinoma in a 29-year-old white woman with multiple adverse prognostic factors includ-ing young age, Nottingham grade 3, Ki-67 proliferation rate of 86%, an axillary lymph node positive for cancer, lack of response to neoadjuvant chemotherapy, and lymphovascular invasion. Pathological characteristics and clinical records of 841 TNBCs diagnosed between 1994 and 2015 in four major oncologic centers from Sardinia, Italy, were reviewed. shown in Table 1, the number of ER-positive cases was 1,120, and the number of PgR-positive cases was 942. Prognostic factors of Guillain-Barré syndrome after intravenous immunoglobulin or plasma exchange. HER2-positive breast cancer is more aggressive and more likely to spread than HER2-negative breast cancer. The positive and negative predictive values (PPV and NPV respectively) are the proportions of positive and negative results in statistics and diagnostic tests that are true positive and true negative results, respectively. Our retrospective analysis addressed prognostic factors for short- and long-term outcomes of patients (pts) with TNBC pts treated in routine clinical practice. Urru SAM, Gallus S, Bosetti C, Moi T, Medda R, Sollai E, et al. Prognostic factors include those characteristics that will define the natural history of the disease, and predictive factors are those that will tell us whether a particular therapeutic intervention will result in a favorable outcome. Several factors have been associated with a better overall prognosis: Being female, rapid (vs. insidious) onset of symptoms, older age of first episode, predominantly positive (rather than negative) symptoms, presence of mood symptoms, and good pre-illness functioning. Moreover, TOP2A was independently associated with DMFS in the HR+/HER2− subtype. The lymph node ratio as an independent prognostic factor for node-positive triple-negative breast cancer. To calculate the combined p value for the pooled prognostic and predictive datasets, we let pij denote the p value for gene i (where i = 1–TOT) in the prognostic or predictive dataset j (where j = 1 or 2) for disease subtype k (where k = 1 for an ER‐positive tumor and 2 for an ER‐negative tumor). Oncotarget. negative negative negative negative positive negative age diminished reflexes pneumonia coma functional admission Score u z yes (Katz Index) functional status at 3 semi-annual inter- 2 vals post-stroke 3 0 z to determine the prognostic impor- tance of age, asso- ciated illness, ear- ly recovery & prcsence of more than one stroke (1) 138 Background: Negative lymph node (NLN) count has been reported to associate with the prognosis of various cancers. NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. They are also more likely to come back after treatment. Prognostic factors specific to each entity have not been adequately explored. prognostic factors for short- and long-term outcomes of patients (pts) with TNBC pts treated in routine clinical practice. In other subtypes, positive LN status was an independent negative prognostic factor. These results demonstrated that the expression of MMP11 and CD2 are independent prognostic factors for HR−/HER2+ breast cancer. Therefore, we conducted this retrospective, dual-institutional study in order to shed some more light on these issues. The X-tile program was used to determine the optimal cutoffs for NLN count. Prognostic factors of node-negative large tumours. Forty-one HIV-positive patients and 45 HIV-negative patients were identified. 53(3):598-604. No prognostic differences between the patients with N1, N2 or N3 disease subtypes (p=0.78) were detected. 1999 Aug 11. To conclude, this study identified discontinuation of whole-brain radiotherapy and presence of triple-negative breast cancer as poor prognostic factors. Overall survival was 38.4% and it was significantly higher in the patients with negative margins and nodes. HIV-positive patients were younger, more likely to present with seizures and elevated serum LDH levels. Goals for this study were: 1) to determine whether HPV-positive and HPV-negative OPSCCs have distinct prognostic factors, and 2) to explore the prognostic significance of sex and race in OPSCC after HPV stratification Study Design: Retrospective case series. BACKGROUND: The objective of this study was to evaluate prognostic factors of local and distant recurrence in patients diagnosed with T1a and T1b, lymph node‐negative breast carcinoma (BC) with emphasis on human epidermal growth factor receptor 2 (HER2) status. The prognostic significance of positive peritoneal cytology in patients with early-stage endometrial cancer (Stage 1 or 2) is controversial and perhaps depends on the presence of other factors. Abstract. Of the more traditional prognostic factors related to Among the patients in the 2+ range for HER2, 65.2% (15/23) were positive for HER2 expression as examined by the fluores- Author contributions. ... Clearly, this is a prognostic as well as predictive indicator. This means that HER2-positive breast cancer has a less favourable prognosis than HER2-negative breast cancer. To provide further information on the clinical and pathological prognostic factors in triple-negative breast cancer (TNBC), for which limited and inconsistent data are available. Only N0 versus N1–3 classification was significant. Purpose: To analyze prognostic and predictive effects of immunohistochemical factors within a randomized study of high-dose versus standard-dose chemotherapy in high-risk breast cancer with >10 involved lymph nodes. This study aims to reveal the prognostic value of NLN count in breast cancer. For lymph node-negative patients, only tumor size and grade were significant prognostic factors. The relationship of other prognostic factors with positive peritoneal cytology remains unclear. Prognostic factors for systemic relapses and for … Abstract 4166Background:. Clinical and pathological factors influencing survival in a large cohort of triple-negative … Age at diagnosis Prognostic factors in node‐positive carcinoma of the penis Prognostic factors in node‐positive carcinoma of the penis Pandey, Durgatosh; Mahajan, Vikash; Kannan, R. Ravi 2006-02-01 00:00:00 Background: Lymph node metastasis is the most important prognostic factor in patients with carcinoma of the penis. In this article, we have reviewed the outcome of the patients with pathologic … Patient and methods. 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